Prediction of characteristics and performance of high gradient magnetic separator
published date: 2019/4/24
Magnetic magnetic separator
PTMS MAGNETIC SEPARATOR
what is magnetic separation used for?
The growing number of biopharmaceutical markets and upstream fermentations have created a strong demand for new downstream purification methods. Magnetic separation has been known for many years as a promising candidate for direct capture tools in protein purification, but the lack of suitable GMP-compliant purification equipment has hampered the release of this technology in large-scale biological processing. . To solve this bottleneck, the principle of the “rotor-stator” high gradient magnetic separator has been completely redesigned to meet the stringent requirements of modern cGMP biotechnology purification processes. To meet regulatory requirements, the separation chamber has been redesigned to allow for efficient cleaning and sterilization while maintaining excellent separation capabilities and efficiency. Two commercially available magnetic particles are used to validate key performance data and determine system-related parameters to calculate process performance data optimized for the new magnetic separation process. With a separation volume of more than 400 grams of magnetic particles per separation and a recovery of more than 99% per liter, the system can process more than 200 liters of crude feed per day and capture more than 1.6 kilograms of target compound. Two commercially available magnetic particles are used to validate key performance data and determine system-related parameters to calculate process performance data optimized for the new magnetic separation equipment process. The volume and separation efficiency per liter of separation chamber exceeds 400 grams of magnetic particles, and the recovery rate exceeds 99%. The system can process more than 200 liters of crude oil raw material per day and capture more than 1.6 kilograms of target compound. Two commercially available magnetic particles are used to validate key performance data and determine system-related parameters to calculate process performance data optimized for the new magnetic separation equipment process. With a separation volume of more than 400 grams of magnetic particles per separation and a recovery of more than 99% per liter, the system can process more than 200 liters of crude feed per day and capture more than 1.6 kilograms of target compound.